The matrix reloaded: the evolution of regenerative hydrogels

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• 作者：Esmaiel Jabbari¹ ; ⁸ ; ^{jabbari@mailbox.sc.edu" class="auth_mail" title="E-mail the corresponding author} ; Jeroen Leijten² ; ³ ; ⁸ ; Qiaobing Xu⁴ ; ⁸ ; ^{Qiaobing.Xu@tufts.edu" class="auth_mail" title="E-mail the corresponding author} ; Ali Khademhosseini² ; ³ ; ⁵ ; ⁶ ; ⁷ ; ^{alik@rics.bwh.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Materials Today
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：19
• 期：4
• 页码：190-196
• 全文大小：1420 K

文摘

Cell-laden hydrogels can regenerate lost, damaged or malfunctioning tissues. Clinical success of such hydrogels is strongly dependent on the ability to tune their chemical, physico-mechanical, and biological properties to a specific application. In particular, mimicking the intricate arrangement of cell-interactive ligands of natural tissues is crucial to proper tissue function. Natural extracellular matrix elements represent a unique source for generating such interactions. A plethora of extracellular matrix-based approaches have been explored to augment the regenerative potential of hydrogels. These efforts include the development of matrix-like hydrogels, hydrogels containing matrix-like molecules, hydrogels containing decellularized matrix, hydrogels derived from decellularized matrix, and decellularized tissues as reimplantable matrix hydrogels. Here we review the evolution, strengths and weaknesses of these developments from the perspective of creating tissue regenerating hydrogels.