Pituitary dendritic cells communicate immune pathogenic signals
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- 作者：Erin Glennona ; 1 ; Ulrike W. Kaunznera ; 1 ; Khatuna Gagnidzea ; Bruce S. McEwenb ; Karen Bullocha ; bulloch@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pituitary gland ; Dendritic cell ; Folliculo-stellate cell ; Lipopolysaccharide ; Glucocorticoids ; Annexin A1
- 刊名：Brain, Behavior, and Immunity
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：50
- 期：Complete
- 页码：232-240
- 全文大小：1612 K
文摘
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The pituitary contains resident non-lymphoid dendritic cells (DC’s).
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LPS challenge causes pituitary DC’s to secrete pro-inflammatory cytokines.
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Pituitary DC cytokines activate the release of GCs from the adrenals via ACTH.
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Pituitary DC’s express annexin A1, indicating a role in attenuating the GC response.
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Pituitary DC’s are an immune sentinel for initial shaping of the immune response.