- 作者：Justin W. Collins ; Stavros Tyritzis ; Tommy Nyberg ; Martin Schumacher ; Oscar Laurin ; Dinyar Khazaeli ; Christofer Adding ; Martin N. Jonsson ; Abolfazl Hosseini ; N. Peter Wiklund
- 关键词：Urinary bladder neoplasms ; Radical cystectomy ; Robotics ; RARC ; Surgical technique
- 刊名：European Urology
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：64
- 期：4
- 页码：654-663
- 全文大小：1853 K
Background
Although open radical cystectomy (ORC) remains the gold standard of care for muscle-invasive bladder cancer, robot-assisted radical cystectomy (RARC) continues to gain wider acceptance. In this article, we focus on the steps of RARC, describing our approach, which has been developed over the past 10 yr. Totally intracorporeal RARC aims to offer the benefits of a complete minimally invasive approach while replicating the oncologic outcomes of open surgery.Objective
We report our outcomes of a totally intracorporeal RARC procedure, describing step by step our technique and highlighting the variations on this standard template of nerve-sparing and female organ-preserving approaches in men and women.
Design, setting, and participants
Between December 2003 and October 2012, a total of 113 patients (94 male and 19 female) underwent totally intracorporeal RARC.
Surgical procedure
We performed RARC, extended pelvic lymph node dissection, and a totally intracorporeal urinary diversion (UD) in all patients. In the accompanying video, we focus on the standard template for RARC, also describing nerve-sparing and female organ-preserving approaches.
Outcome measurements and statistical analysis
Complications and oncologic outcomes are reported, including overall survival (OS) and cancer-specific survival (CSS) using Kaplan-Meier analysis.
Results and limitations
RARC with intracorporeal UD was performed in 113 patients. Mean age was 64 yr (range: 37-84). Forty-three patients underwent intracorporeal ileal conduit, and 70 had intracorporeal neobladder. On surgical pathology, 48 % of patients had ¡ÜpT1 disease, 27 % had pT2 disease, 13 % had pT3 disease, and 12 % had pT4 disease. The mean number of lymph nodes removed was 21 (range: 0-57). Twenty percent of patients had lymph node-positive disease. Positive surgical margins occurred in six cases (5.3 % ). Median follow-up was 25 mo (range: 3-107). We recorded a total of 70 early complications (0-30 d) in 54 patients (47.8 % ), with 37 patients (32.7 % ) having Clavien grade ¡Ý3. Thirty-six late complications (>30 d) were recorded in 30 patients (26.5 % ), with 20 patients (17.7 % ) having Clavien grade ¡Ý3. One patient (0.9 % ) died within 90 days of operation from pulmonary embolism. Using Kaplan-Meier analysis, CSS was 81 % at 3 yr and 67 % at 5 yr.
Conclusions
Our structured approach to RARC has enabled us to develop this complex service while maintaining patient outcomes and complication rates comparable with ORC series. Our results demonstrate acceptable oncologic outcomes and encouraging long-term CSS rates.