Cytotoxic tetraoxygenated xanthones from the bark of Garcinia schomburgkiana

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• 作者：Hau T. Vo ; Ngoc-Tuyet T. Nguyen ; Hieu T. Nguyen ; Khoa Q. Do ; Joseph D. Connolly ; Gerhard Maas ; J?rg Heilmann ; Udo R. Werz ; Hung D. Pham ; Lien-Hoa D. Nguyen
• 关键词：Garcinia schomburgkiana ; Guttiferae ; 6-O-Demethyloliverixanthone ; Schomburgxanthone ; Xanthones ; Cytotoxicity
• 刊名：Phytochemistry Letters
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：5
• 期：3
• 页码：553-557
• 全文大小：265 K

文摘

Two new tetraoxygenated xanthones, 6-O-demethyloliverixanthone and schomburgxanthone, together with cowanin, cowanol, fuscaxanthones A and B, 3-isomangostin hydrate, and 1,7-dihydroxyxanthone, were isolated from the bark of Garcinia schomburgkiana. Their structures were elucidated using 1-D and 2-D NMR techniques as well as chemical methods. Five of the isolated compounds were tested regarding their cytotoxicity against HeLa cells and the results showed that fuscaxanthone B and cowanin possessed remarkable activity with IC₅₀ values of 2.4 ¡À 0.2 and 2.7 ¡À 0.3 ¦Ìg/ml, respectively, using an MTT assay.