MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance

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• 作者：Nora Rauch<sup>1sup> ; Oleksii S Rukhlenko<sup>1sup> ; Walter Kolch<sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>3sup> ; Boris N Kholodenko<sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>3sup><sup> ; sup><sup>boris.kholodenko@ucd.iesup>
• 刊名：Current Opinion in Structural Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：41
• 期：Complete
• 页码：151-158
• 全文大小：892 K
• 卷排序：41

文摘

Distinct cell fates result from different spatiotemporal MAPK dynamics. Versatile MAPK dynamics include adaptive/sustained activity, switches and oscillations. MAPK dynamics changes caused by mutations lead to developmental disorders and cancer. Drug resistance inevitably develops for RAF and MEK inhibitors. Two RAF inhibitors ineffective on their own can abolish drug resistance when combined.