Steroidal monoglycosides from the Far Eastern starfish Hippasteria kurilensis

详细信息    查看全文

• 作者：Alla A. Kicha ; Natalia V. Ivanchina ; Anatoly I. Kalinovsky ; Pavel S. Dmitrenok ; Valentin A. Stonik
• 关键词：Polyhydroxylated steroids ; Glycosides ; Starfish ; Hippasteria kurilensis ; Biosynthesis
• 刊名：Steroids
• 出版年：2009
• 出版时间：February 2009
• 年：2009
• 卷：74
• 期：2
• 页码：238-244
• 全文大小：631 K

文摘

Five new steroidal monoglycosides, kurilensosides E (1), F (2), G (3), H (4) and 15-O-sulfate of echinasteroside C (5) were isolated along with the previously known echinasteroside C (6) from the alcoholic extract of the Far Eastern starfish Hippasteria kurilensis collected near Kuril Islands. Compounds 1–3 were determined to contain unusual polyhydroxysteroidal aglycons lacking 6-hydroxy group. Aglycon moiety of kurilensoside H (4) was shown to be the first case of marine polar steroids containing 4,5-epoxy functionality. Hypothetic pathways of the biosynthesis of polyhydroxysteroids and related glycosides in starfish and the existence of the late C-6 oxidation pathway in H. kurilensis are discussed.