Computer simulation of cardiac cryoablation: Comparison with in vivo data
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- 作者：Michael H ; ler ; Gerald Fischer ; Michael Seger ; Rol ; Kienast ; Claudia-Nike Nowak ; Daniel Pehb枚ck ; Florian Hintringer ; Christian Baumgartner
- 关键词：Cardiac cryoablation ; Modeling and simulation ; Pennes&rsquo ; bioheat equation ; Finite element method ; In vivo validation ; Temperature profile
- 刊名：Medical Engineering and Physics
- 出版年：December, 2013
- 年：2013
- 卷：35
- 期：12
- 页码：1754-1761
- 全文大小：1215 K
文摘
Simulation of cardiac cryoablation by the finite element method can contribute to optimizing ablation results and understanding the effects of modifications prior to time-consuming and expensive experiments. In this work an intervention scenario using a 9 Fr 8 mm tip applicator applied to ventricular tissue was simulated using the effective heat capacity model based on Pennes鈥?bioheat equation. Using experimentally obtained refrigerant flow rates and temperature profiles recorded by a thermocouple located at the tip of the applicator the cooling performance of the refrigerant was estimated and integrated by time and temperature dependent boundary conditions based on distinct phases of a freeze-thaw cycle. Our simulations exhibited a mean difference of approximately 6 掳C at the applicator tip compared to temperature profiles obtained during in vivo experiments. The presented model is a useful tool for simulation and validation of new developments in clinical cardiac cryoablation.