Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors

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• 作者：Toru Nakata^a ; Hiromichi Shimizu^a ; ^b ; Sayaka Nagata^a ; Go Ito^a ; ^c ; Satoru Fujii^a ; Kohei Suzuki^a ; Ami Kawamoto^a ; Fumiaki Ishibashi^a ; Reiko Kuno^a ; Sho Anzai^a ; Tatsuro Murano^a ; Tomohiro Mizutani^a ; Shigeru Oshima^a ; Kiichiro Tsuchiya^a ; Tetsuya Nakamura^d ; Katsuto Hozumi^e ; Mamoru Watanabe^a ; Ryuichi Okamoto^a ; ^f ; ^{rokamoto.gast@tmd.ac.jp}
• 关键词：Notch ; Intestinal tumor ; APC ; Jag1 ; RBPJ
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1296-1303
• 全文大小：5560 K
• 卷排序：482

文摘

Notch signaling is activated in LGR5+ve cells of APC-deficient intestinal tumors. Lack of Jag1 but not RBPJ disrupts stem cell niche formation in those tumors. Lack of Jag1 reduces the proliferation activity of APC-deficient intestinal tumors.