Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model
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- 作者：Jang Won Parka ; 1 ; Young-Pil Yuna ; 1 ; Kyeongsoon Parkb ; Jae Yong Leea ; c ; Hak-Jun Kima ; Sung Eun Kima ; sekim10@korea.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Hae-Ryong Songa ; songhae@korea.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ibuprofen ; PLGA ; Porous microspheres ; Anti-inflammatory effect ; Osteoarthritis
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：265-273
- 全文大小：2726 K
文摘
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Ibuprofen-loaded porous microspheres were fabricated by a fluidic device.
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Ibuprofen from IBU/PMSs was released in a sustained manner for 63 days.
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IBU/PMSs suppressed the progression of MIA-induced OA in the rat model.