Challenges and strategies for the eradication of the HIV reservoir
详细信息 查看全文
- 作者：Jason T Kimata<sup>1sup><sup> ; sup><sup>jkimata@bcm.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; Andrew P Rice<sup>1sup> ; Jin Wang<sup>2sup>
- 刊名：Current Opinion in Immunology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：65-70
- 全文大小：613 K
文摘
- •
Memory CD4<sup>+sup> T cells with latently integrated proviruses are a major barrier to curing HIV infection.
- •
Proviral integration within genes involved in cancer may contribute to clonal proliferation of latently infected CD4<sup>+sup> T cells.
- •
Challenges to clearing viral reservoirs within B cell follicles of lymph nodes.
- •
Immunotherapy shows promise for clearing HIV infection.
- •
Combination approaches may be necessary to cure HIV infection.