Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients
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- 作者：Speer ; Andrew M. ; Kimbrell ; Timothy A. ; Wassermann ; Eric M. ; D. Repella ; Jennifer ; Willis ; Mark W. ; et. al.
- 关键词：Transcranial magnetic stimulation ; regional cerebral blood flow ; depressed ; high frequency (20 Hz) ; low frequency (1 Hz) ; positron emission tomography
- 刊名：Biological Psychiatry
- 出版年：2000
- 出版时间：December 15, 2000
- 年：2000
- 卷：48
- 期：12
- 页码：1133-1141
- 全文大小：824 K
文摘
Background: High (10–20 Hz) and low frequency (1–5 Hz) repetitive transcranial magnetic stimulation (rTMS) have been explored for possible therapeutic effects in the treatment of neuropsychiatric disorders. As part of a double-blind, placebo-controlled, crossover study evaluating the antidepressant effect of daily rTMS over the left prefrontal cortex, we evaluated changes in absolute regional cerebral blood flow (rCBF) after treatment with 1- and 20-Hz rTMS. Based on preclinical data, we postulated that high frequency rTMS would increase and low frequency rTMS would decrease flow in frontal and related subcortical circuits.