Antiobesity effects of kimchi in diet-induced obese mice

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• 作者：Meizi Cui^a ; Hee-Young Kim^a ; Kyung Hee Lee^a ; Ji-Kang Jeong^a ; ^b ; Ji-Hee Hwang^c ; Kyu-Young Yeo^c ; Byung-Hee Ryu^c ; Jung-Ho Choi^c ; Kun-Young Park^a ; ^b ; ^{kunypark@pusan.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：antiobesity ; C57BL/6 mice ; high-fat diet ; kimchi ; obesity-related genes
• 刊名：Journal of Ethnic Foods
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：2
• 期：3
• 页码：137-144
• 全文大小：1318 K

文摘

The present study was investigated to confirm the antiobesity effect of kimchi in high-fat diet-induced obese C57BL/6 mice.

Methods

Mice in the high-fat diet (HFD) group, standardized kimchi (S-Kimchi) group, and Korean commercial kimchi (D-Kimchi) group, but not in the normal-diet group, were fed a high-fat diet (HFD) for the first 4 weeks to induce obesity. From the 5^th to 8^th weeks, the S- and D-Kimchi groups were fed an HFD containing 10% of S-Kimchi or D-Kimchi, respectively. After 8 weeks, mice were sacrificed and obesity-related factors were determined.

Results

Body and adipose tissue weights were significantly lower in the kimchi-treated groups than in the HFD group. In particular, in the D-Kimchi group, serum levels of triglyceride, total cholesterol, low-density lipoprotein-cholesterol, insulin, and leptin were significantly lower, and serum levels of high-density lipoprotein-cholesterol and adiponectin were markedly higher than those in the HFD group. Moreover, hepatic mRNA expression of adipogenesis-related genes (CCAAT/enhance-binding protein-α, peroxisome proliferator-activated receptor-γ, sterol regulatory element-binding protein-1c, and fatty acid synthase) in the kimchi-treated groups were lower than those in the HFD group, but fatty acid oxidation-related carnitine palmitoyltransferase-1 expressions were higher. In addition, kimchi decreased the mRNA levels of the inflammation-related monocyte chemotactic protein-1 and interleukin-6 in epididymal fat tissue.

Conclusion

Administration of kimchi, especially of D-Kimchi, which contained Leuconostoc mesenteroides DRC 0211 starter and other subingredients, exhibited antiobesity activity by reducing body weight gains and adipose tissue weights; modulating serum lipid profiles and hepatic lipogenesis; regulating serum insulin, leptin, and adiponectin levels; and reducing adipocyte size and inflammatory response in epididymal fat tissues.