刊名:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
出版年:2017
出版时间:January 2017
年:2017
卷:1865
期:1
页码:43-54
全文大小:2478 K
卷排序:1865
文摘
Human Kinome has a variable presence of intrinsically disordered regions (IDRs). IDRs adjacent to the kinase domains observe variable evolutionary pressure. FAK1 is a central hub of a network of Kinases with IDRs adjacent to kinase domain. FAK1 IDRs are spatially conserved across evolution. FAK1 relays cytoskeletal remodeling preferentially through IDR-interacting proteins.