Long chain n-3 polyunsaturated fatty acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKCε/δ-induced ERK pathways
详细信息 查看全文
- 作者：Lucie Chauvina ; Caroline Goupillea ; b ; Charly Blanca ; Michelle Pinaulta ; Isabelle Domingoa ; Cyrille Guimaraesa ; Philippe Bougnouxa ; b ; Stephan Chevaliera ; c ; Karine Mahé ; oa ; c ; karine.maheo@univ-tours.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CL ; Cardiolipin ; DAG ; Diacylglycerol ; DHA ; Docosahexaenoic acid ; DMSO ; Dimethyl sulfoxide ; ECL ; Enhanced chemiluminescence ; EGFR ; Epidermal growth factor receptor ; EPA ; Eicosapentaenoic acid ; ERK ; Extracellular signal-related kinase ; HP-TLC ; High performance thin layer chromatography ; MEK ; Mitogen extracellular signal-regulated kinase ; MW ; Molecular weight ; n-3 PUFA ; n-3 Polyunsaturated fatty acids ; n-3 LCPUFA ; n-3 Long chain polyunsaturated fatty acids ; NMU ; N-nitroso-N-methylurea ; PA ; Phosphat
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1861
- 期：4
- 页码：380-390
- 全文大小：2119 K
文摘
- •
Docetaxel induces phosphatidic acid leading to PKC activation in cancer cells.
- •
PKCε/δ have been identified as mediators of ERK1/2 activation by docetaxel.
- •
P-ERK levels in tumors are correlated with poor taxane response.
- •
Incorporation of DHA in phospholipids is associated to a decreased PKC activity.
- •
DHA represses ERK and Akt pathways in mammary tumors and improve taxane efficacy.