UNC-51-like kinase 1 expression in radical nephrectomy specimens as a predicting factor of progression-free survival in patients with metastatic renal cell carcinoma treated with mammalian target of rapamycin inhibitors
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- 作者：Masatomo Nishikawa ; M.D. ; Ph.D. ; Hideaki Miyake ; M.D. ; Ph.D. ; hideakimiyake@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Liu Bing ; M.D. ; Masato Fujisawa ; M.D. ; Ph.D.
- 关键词：Metastatic renal cell carcinoma ; Autophagy ; UNC-51-like kinase 1 ; Mammalian target of rapamycin inhibitor
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：33
- 期：12
- 页码：506.e1-506.e7
- 全文大小：385 K
文摘
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Significance of autophagy was analyzed in patients with mRCC treated with mTOR inhibitors.
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ULK1 may be a strong prognostic factor in patients with mRCC treated with mTOR inhibitors.
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Liver metastasis was also independently associated with PFS of these patients.