刊名:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
出版年:2017
出版时间:February 2017
年:2017
卷:1864
期:2
页码:243-254
全文大小:1839 K
卷排序:1864
文摘
Astrocyte αvβ3 integrin engages neuronal Thy-1 in trans to induce neurite shortening. Neuronal β3 integrin Thy-1 cis interaction appears dispensable for neurite retraction. αvβ3 stimulation of Thy-1 in trans clusters Thy-1/CBP/Csk in a multi-protein complex CBP is a transmembrane transducer for Thy-1 signaling in neurons. Integrin-Thy-1 binding induces neurite retraction by inhibiting Src and activating RhoA.