- 作者：Sanjeev Kumar ; Adnan Munkarah ; Haitham Arabi ; Sudeshna B ; yopadhyay ; Assaad Semaan ; Kinda Hayek ; Gunjal Garg ; Robert Morris ; Rouba Ali-Fehmi
- 关键词：endometriosis ; ovarian cancer ; prognosis ; survival
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：2011
- 出版时间：January 2011
- 年：2011
- 卷：204
- 期：1
- 页码：63.e1-63.e7
- 全文大小：1760 K
Objective
The objective of the study was to evaluate the prognosis of ovarian cancer arising in endometriosis.Study Design
We retrospectively compared 42 cases of endometriosis-associated ovarian cancer (EAOC) with 184 cases of ovarian carcinoma without endometriosis (OC).
Results
The median age in the EAOC group was 52 vs 59 years in OC (P < .05). In comparison with OC, the EAOC patients were more likely to have low-grade (21 % vs 8 % ; P = .04) and early-stage tumors (International Federation of Gynecology and Obstetrics I and II combined) (49 % vs 24 % ; P = .002). Clear cell (21 % vs 2 % ) and endometrioid (14 % vs 3 % ) tumors were more frequent in EAOC, whereas mucinous tumors were more prevalent in OC (P = .001). The median survival (199 vs 62 months) and the 5 year survival (62 % vs 51 % ) were better for EAOC when compared with OC (P = .038). After controlling for age, stage, grade, and treatment, association with endometriosis was not an independent predictor of better survival in ovarian cancer.
Conclusion
As such, EAOC has a much better survival rate than OC. This could be explained by the higher prevalence of early-stage and low-grade tumors in EAOC when compared with OC.