Prenatal exposure to di(2-ethylhexyl) phthalate impairs development of the mouse neocortex
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- 作者：Munekazu Komadaa ; komada@dpc.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yuuya Gendaib ; yuuya-gendai@me.pikara.ne.jp" class="auth_mail" title="E-mail the corresponding author ; Nao Kagawab ; kagawa@life.kindai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Tetsuji Nagaob ; tnagao@life.kindai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：DEHP ; Di(2-ethylhexyl) phthalate ; CNS ; central nervous system ; E ; embryonic day ; P ; postnatal day ; PLP ; periodate lysin paraformaldehyde ; PBS ; phosphate-buffered saline ; Tuj1 ; neural class III β-tubulin ; BrdU ; bromo-deoxyuridine ; CldU ; chloro-deoxyuridine ; IdU ; iodo-deoxyuridine ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; H&E ; hematoxylin and eosin ; CP ; cortical plate ; MHEP ; mono-(2-ethylhexyl) phthalate ; VZ ; ventricular zone ; CERHR ; Center For The Evaluation Of Risk To Human Reproduction ; FSCJ
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：259
- 期：Complete
- 页码：69-79
- 全文大小：7331 K
文摘
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We performed histologic analyses of fetal and newborn mice prenatally exposed to DEHP.
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Prenatal DEHP exposure led to the reduction of proliferation and neurogenesis, and an increase in cell death in the dorsal telencephalon of fetal mice.
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Prenatal DEHP exposure led to an abnormal neuronal distribution and reduction of neurons in the neocortex of newborn mice.