Increased inhibitory synaptic activity in the hippocampus (CA1) of genetic absence epilepsy rats: Relevance of kindling resistance
详细信息 查看全文
- 作者：Nihan Ç ; arç ; aka ; Ergin Dilekö ; zb ; Rezzan Gü ; lhanc ; Rü ; ştü ; Onurd ; Filiz Yılmaz Onatc ; fonat@marmara.edu.tr" class="auth_mail" title="E-mail the corresponding author ; fonatmarmara@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yıldırım Sarae ; yildirimsara@gmail.com" class="auth_mail" title="E-mail the corresponding author ; ysara@hacettepe.edu.tr" class="auth_mail" title="E-mail the corresponding author
- 关键词：GABA ; GAERS ; Absence epilepsy ; Paired-pulse depression ; Electrophysiology ; In-vivo
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：126
- 期：Complete
- 页码：70-77
- 全文大小：1236 K
文摘
- •
Kindling resistance was overcome by the administration of supra-threshold stimuli, with a delayed progression to stage 5 in GAERS.
- •
GAERS displayed a significant increase in hippocampal excitability at stage 2.
- •
The paired-pulse despression (PPD) was more pronounced on CA1 synapses of control GAERS than in the control Wistar rats.
- •
There was a decrease in PPD in the Wistar rats as the kindling progress has advanced, and reached at its highest grade upon achievement of stage 5.