Hippocampal to basal forebrain transport of Mn²⁺ is impaired by deletion of KLC1, a subunit of the conventional kinesin microtubule-based motor

详细信息    查看全文

• 作者：Christopher S. Medina^a ; ¹ ; Octavian Biris^b ; ¹ ; Tomas L. Falzone^c ; Xiaowei Zhang^d ; Amber J. Zimmerman^a ; Elaine L. Bearer^a ; ^b ; ^d ; ^e ; ² ; ^{elaine.bearer@gmail.com} ; ^{ebearer@salud.unm.edu}
• 关键词：Kinesin-1 ; Kinesin light chain-1 ; Axonal transport ; Manganese-enhanced magnetic resonance imaging (MEMRI) ; Hippocampal-forebrain circuit ; Statistical parametric mapping
• 刊名：NeuroImage
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：145
• 期：part_PA
• 页码：44-57
• 全文大小：1720 K
• 卷排序：145

文摘

This is the first study to test the role of kinesin-1 in axonal transport within the central nervous system. KLC1 deletion leads to a reduction of Mn2+ transport from CA3 to the septal nuclei. Time lapse MRI of Mn2+ provides a method to measure axonal transport in the living brain.