Oxidative stress induces mitotic arrest by inhibiting Aurora A-involved mitotic spindle formation

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• 作者：Guang-Fei Wang^a ; ¹ ; Qincai Dong^b ; ¹ ; Yuanyuan Bai^b ; Jing Yuan^c ; Quanbin Xu^b ; Cheng Cao^b ; ^{cao_c@sohu.com} ; Xuan Liu^b ; ^{liux931932@163.com}
• 关键词：CIN ; chromosomal instability ; CKIs ; CDK inhibitors ; DDC ; sodium diethyldithiocarbamate trihydrate ; GSK-3 ; glycogen synthase kinase 3 ; NAC ; N-acetyl-L-cysteine ; PCM ; pericentriolar material ; PCNT ; pericentrin ; ROS ; reactive oxygen species ; SAC ; spindle assembly checkpoint ; SOD ; superoxide dismutase ; TPX2 ; Target Protein for Xenopus kinesin-like protein 2
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：177-187
• 全文大小：1450 K
• 卷排序：103

文摘

Exogenous and endogenous ROS both induce mitotic arrest. ROS result in delayed formation and abnormal function of the mitotic spindle. Aurora A is hyperphosphorylated in early mitosis under oxidative stress. The centrosomal localization of Aurora A is not affected by hyperphosphorylation.