The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease
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- 作者：Adrienne L. King<sup>asup><sup> ; sup><sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>aking125@kennesaw.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; Sudheer K. Mantena<sup>asup><sup> ; sup><sup>1sup><sup> ; sup><sup>sushdheer@yahoo.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Kelly K. Andringa<sup>asup><sup> ; sup><sup>kellyandringa@uabmc.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; Telisha Millender-Swain<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>telishaswain@uabmc.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; Kimberly J. Dunham-Snary<sup>bsup><sup> ; sup><sup>3sup><sup> ; sup><sup>Kimberly.dunhamsnary@queensu.ca" class="auth_mail" title="E-mail the corresponding authorsup> ; Claudia R. Oliva<sup>csup><sup> ; sup><sup>coliva@uabmc.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; Corinne E. Griguer<sup>csup><sup> ; sup><sup>cegriguer@uabmc.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; Shannon M. Bailey<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>shannonbailey@uabmc.edu" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：ALT ; alanine aminotransferase ; CN-PAGE ; clear native polyacrylamide gel electrophoresis ; CsA ; cyclosporin A ; GSH ; glutathione ; HIF1α ; hypoxia-inducible factor 1 alpha ; iNOS ; inducible nitric oxide synthase ; MPT ; mitochondrial permeability transition ; NO ; nitric oxide ; ONOO- ; peroxynitrite ; RCR ; respiratory control ratio ; RNS ; reactive nitrogen species ; ROS ; reactive oxygen species ; SAM ; S-adenosylmethionine ; O2&bull ; - ; superoxide anion
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：9
- 期：Complete
- 页码：188-197
- 全文大小：1220 K
文摘
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Rats were fed control and alcohol diets±S-Adenosylmethionine (SAM) for 5 weeks.
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SAM prevented alcohol-induced liver hypoxia.
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SAM normalized mitochondrial respiration in alcohol-fed rats.
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SAM normalized sensitivity to undergo the mitochondrial permeability transition in alcohol-fed rats.
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SAM normalized nitric oxide-mediated respiratory inhibition in alcohol-fed rats.