Cholinergic activation affects the acute and chronic antinociceptive effects of morphine

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• 作者：Kinga Gawel^a ; ^b ; Ewa Gibula-Bruzda^a ; Marcin Dziedzic^c ; Malgorzata Jenda-Wojtanowska^a ; Marta Marszalek-Grabska^a ; Jerzy Silberring^d ; Jolanta H. Kotlinska^a ; ^{jolka.kotlinska@umlub.pl}
• 关键词：Donepezil ; Rivastigmine ; Morphine ; Tolerance ; Hot plate ; Mice
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：169
• 期：Complete
• 页码：22-32
• 全文大小：1412 K
• 卷排序：169

文摘

Donepezil and rivastigmine enhance and prolong acute antinociceptive effects of morphine. Muscarinic receptors are involved in these effects of cholinesterase inhibitors. Cholinergic drugs inhibit the development but not expression of tolerance to morphine analgesia.