Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway
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- 作者：Deep Raj Sharmaa ; Aditya Sunkariaa ; Willayat Yousuf Wania ; Reeta Kumari Sharmaa ; Deepika Vermaa ; Kumari Priyankaa ; Amanjit Balb ; Kiran Dip Gilla ; kdgill2002@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：ROS ; reactive oxygen species ; PGC-1α ; peroxisome proliferator activated receptor gamma co-activator 1a ; NRF-1 ; nuclear respiratory factor-1 ; NRF-2 ; nuclear respiratory factor-2 ; Tfam ; mitochondrial transcription factor A ; ETC ; electron transport chain ; MtDNA ; mitochondrial DNA ; HC ; hippocampus ; CS ; corpus striatum
- 刊名：Neurotoxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：51
- 期：Complete
- 页码：116-137
- 全文大小：8451 K
文摘
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Quercetin increases the mRNA levels of mitochondrial and nuclear encoded subunits.
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It increases the mtDNA copy number and mitochondrial content in rat brain.
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It also up regulates mRNA and protein levels of PGC-1α, NRF-1, NRF-2 and Tfam.
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Finally, it also increases mitochondrial number in HC and CS regions of rat brain.