The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination
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- 作者：Yanfang Yea ; c ; Lucy Kirkham-McCarthya ; b ; Robert S. Lahuea ; b ; bob.lahue@nuigalway.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：TNR ; trinucleotide repeat ; MRX ; Mre11-Rad50-Xrs2 complex ; HR ; homologous recombination ; YPD ; yeast extract-peptone-dextrose ; SC ; synthetic complete ; AcK ; acetyl lysine ; K to R ; lysine to arginine substitution mutant ; MRN ; Mre11-Rad50-Nbs1 complex ; SEM ; standard error of the mean
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：1-8
- 全文大小：1378 K
文摘
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The Mre11-Rad50-Xrs2 (MRX) complex helps drive triplet repeat expansions in yeast.
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MRX works independently of homologous recombination to fuel expansions.
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Mre11 nuclease activity is dispensable.
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MRX likely creates an altered TNR substrate for post replication repair action.
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Rad50 is acetylated; Sin3-mediated deacetylation is important for expansions.