Prevalence of latent and reactivated Toxoplasma gondii parasites in HIV-patients from Uganda

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• 作者：Irene Lindströ ; m ; Deogratias H Kaddu-Mulindwa ; Fred Kironde ; Johan Lindh
• 关键词：Toxoplasma gondii ; Seroprevalence ; PCR ; SAG2 ; HIV ; Africa
• 刊名：Acta Tropica
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：100
• 期：3
• 页码：218-222
• 全文大小：164 K

文摘

Untreated Toxoplasma gondii-infections are often fatal in AIDS-patients. Many African countries struck hard by HIV/AIDS exhibit a high seroprevalence of T. gondii, but the rate of reactivated parasites among African HIV-patients has never previously been determined. In this study, IgG-agglutination and PCR was used to analyse blood samples from 130 HIV-positive patients in Uganda. Anti-T. gondii antibodies were detected in 54 % of the patients while 23 % had parasites in the peripheral blood, which indicates active infection. Genotyping of the SAG2-locus revealed the type II allele for most disease-causing strains (60 % ), but all three SAG2-types was represented in our study population. Furthermore, one sample appeared to harbour a recombinant strain, with SAG2 type II but the type I-allele at the BTUB-gene. This study emphasizes the high prevalence of toxoplasmosis among Ugandan HIV-patients and also suggests that recombinant or atypical strains may be present in this part of the world.