Intake of alcohol and risk of adult-onset asthma

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• 作者：Sofie Lieberoth^a ; Vibeke Backer^a ; Kirsten Ohm Kyvik^b ; Lars Rauff Skadhauge^c ; Janne Schurmann Tolstrup^d ; Morten Gr&#248 ; nbæ ; k^d ; Allan Linneberg^e ; Simon Francis Thomsen^f ; ^sft@city.dk
• 关键词：Asthma ; Alcohol ; Epidemiology ; Risk factor ; Population study ; Prospective
• 刊名：Respiratory Medicine
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：106
• 期：2
• 页码：184-188
• 全文大小：196 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences<h3 class=""h3"">Summaryh3><h4 class=""h4"">Aimh4>To examine the association between intake of alcohol and risk of adult-onset asthma.<h4 class=""h4"">Methodsh4>

Using data from two multidisciplinary questionnaire surveys we prospectively studied 19,349 twins, 12-41 years of age, from the nationwide Danish Twin Registry.<h4 class=""h4"">Resultsh4>

The eight-year incidence of asthma was 4.3 % . After adjustment for sex, age, BMI, physical activity, educational level and smoking, the risk of new-onset asthma was significantly related to overall alcohol intake in a U-shaped manner with the lowest risk observed in the group with a moderate weekly intake of alcohol (1-6 units/week), p?=?0.006. The highest risk of asthma was observed in rare/never drinkers (<1 unit/month), OR?=?1.59 (1.25-2.02), p?=?0.000, whereas the risk of asthma in heavy daily drinkers (? units/day) was also increased, however not statistically significant, OR?=?1.13 (0.54-2.36), p?=?0.747. The risk of new-onset asthma was lower for subjects with wine preference (3.3 % ) compared with beer preference (4.3 % ) or no preference (4.4 % ). After multivariable adjustment, wine preference was inversely related to incident asthma compared with beer preference. However, this finding was not statistically significant, OR?=?0.87 (0.51-1.46), p?=?0.590.<h4 class=""h4"">Conclusionh4>

Alcohol intake is associated with new-onset asthma in adults with a U-shaped association between amount of alcohol intake and the risk of asthma.