Pre-eclampsia and the Kidney

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• 作者：Fadi G. Mirza ; Kirsten Lawrence Cleary
• 关键词：chronic renal disease ; kidney ; pre-eclampsia ; pregnancy ; renal function
• 刊名：Seminars in Perinatology
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：33
• 期：3
• 页码：173-178
• 全文大小：178 K

文摘

Pre-eclampsia is a multisystem disorder that is unique to pregnancy, affecting at least 5 % of all gravidas. The mainstay of this diagnosis is a combination of new-onset hypertension and proteinuria. The kidney deserves particular attention because of the physiologic as well as pathologic changes that can affect this vital organ in pregnancy. In fact, there is a major interplay between renal disease and pre-eclampsia. Proteinuria is universal to all cases of pre-eclampsia, yet some cases can progress to acute renal failure. Furthermore, it is well-established that the latter is more frequent in women with underlying renal disease. This chapter reviews the physiologic changes that the human kidney adapts during pregnancy, the impact of pre-eclampsia on the kidney and its function, and the risk of pre-eclampsia in women with chronic renal disease. Two groups that warrant special consideration are pregnant women with systemic lupus erythematosus and those with history of renal transplantation.