Risedronate decreases bone resorption and improves low back pain in postmenopausal osteoporosis patients without vertebral fractures

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• 作者：Seiji Ohtori ; Tsutomu Akazawa ; Yasuaki Murata ; Tomoaki Kinoshita ; Masaomi Yamashita ; Koichi Nakagawa ; Gen Inoue ; Junichi Nakamura ; Sumihisa Orita ; Nobuyasu Ochiai ; Shunji Kishida ; Masashi Takaso ; Yawa
• 关键词：Bone mineral density ; Bone resorption ; Low back pain ; Osteoporosis ; Risedronate ; Vertebra
• 刊名：Journal of Clinical Neuroscience
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：17
• 期：2
• 页码：209-213
• 全文大小：182 K

文摘

Elderly postmenopausal women who have osteoporosis sometimes experience low back pain, however, the relationship between low back pain and osteoporosis in the absence of vertebral fractures remains unclear. We examined the relationship between bone mineral density (BMD), bone resorption and low back pain in elderly female patients who did not have osteoporotic vertebral fractures. The average BMD was 0.675 g/cm² when assessed by dual-energy X-ray absorptiometry (DEXA). Patients were excluded from the study if they had vertebral fractures revealed by radiography, CT scans or MRI. Bisphosphonate (risedronate) was administered for 4 months. The visual analogue scale (VAS) pain score, Roland Morris Disability Questionnaire (RDQ), Short Form-36 (SF-36) questionnaire, BMD and N-terminal telopeptide of type I collagen (NTx; a marker for bone resorption) were examined before and after treatment. DEXA did not increase significantly, but serum and urinary NTx were decreased (−51.4 % and −62.0 % , respectively) after 4 months of risedronate treatment (p < 0.01). The assessment was repeated using the VAS score, RDQ and SF-36, which revealed an improvement after risedronate treatment (p < 0.01). A decrease in serum and urinary NTx was associated with improvement of low back pain, suggesting that despite the absence of vertebral fractures, bone resorption due to osteoporosis may cause low back pain.