The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels

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• 作者：Chong Chen¹ ; Shin Nakagawa ; ^{snakaga@med.hokudai.ac.jp} ; Yan An ; Koki Ito ; Yuji Kitaichi ; Ichiro Kusumi
• 关键词：Brain plasticity ; Chronic stress ; Corticosterone ; Cortisol ; Depression ; Dopamine ; Exercise ; Glucocorticoid receptor ; Medial prefrontal cortex ; Wheel running
• 刊名：Frontiers in Neuroendocrinology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：83-102
• 全文大小：3304 K
• 卷排序：44

文摘

We propose the ‘exercise-glucocorticoid paradox’. Similar to chronic stress, exercise increases glucocorticoid. Chronic stress or glucocorticoid exposure is detrimental to cognition, mood and the brain. Chronic exercise is beneficial to cognition, mood and the brain. CORT functions to elevate dopamine in the mPFC under exercise but not stress.