Dual mechanisms of rapid expression of anxiety-related behavior in pilocarpine-treated epileptic mice
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- 作者：Shintaro Otsuka
- 关键词：BDNF ; brain-derived neurotrophic factor ; EEG ; electroencephalogram ; GFAP ; glial fibrillary acidic protein ; GS ; generalized seizure ; SE ; status epilepticus
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：55-67
- 全文大小：4971 K
文摘
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Status epilepticus was induced for 1.5 and 4.5 h in a pilocarpine mouse model.
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Anxiety-related behavior depended on status epilepticus duration.
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Hippocampal BDNF levels were correlated with anxiety-related behavior.
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BDNF in the hippocampus might cause anxiety-related behavior in adulthood.