Vaginal LPS changed gene transcriptional regulation response to ischemic reperfusion and increased vulnerability of fetal brain hemorrhage
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- 作者：Yupeng Donga ; dongyupeng7@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yoshitaka Kimuraa ; b ; Takuya Itoa ; Clarissa Velayoa ; Takafumi Satoa ; Rika Sugibayashia ; Kiyoe Funamotoa ; Kudo Hitomia ; Keita Iidaa ; Miyuki Endoa ; Naoaki Satoa ; Nobuo Yaegashib
- 关键词：Ischemic reperfusion ; Fetal brain hemorrhage ; LPS ; ATF2 ; P53 ; FECG
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：228-233
- 全文大小：982 K
文摘
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Vaginal LPS increased vulnerability of fetal brain hemorrhage in response to IR.
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Vaginal LPS sensitized the fetal brain via fetal inflammatory reaction like TNF-α.
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Vaginal LPS plus IR triggered a specific phosphorylation of ATF2 at Thr71.
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P53 inhibitor blocked the vaginal LPS induced Phosphorylation of ATF2, completely.
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We suggested that a novel link of JNK-P53-ATF2-HIF-1α under vaginal LPS plus IR.