The effect of dopamine agonists: The expression of GDNF, NGF, and BDNF in cultured mouse astrocytes

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• 作者：Kiyoe Ohta ; Sadako Kuno ; Seiji Inoue ; Erika Ikeda ; Aya Fujinami ; Mitsuhiro Ohta
• 关键词：Parkinson's disease ; Dopamine agonist ; Ropinirole ; Neurotrophic factor ; NGF ; BDNF ; GDNF
• 刊名：Journal of the Neurological Sciences
• 出版年：2010
• 出版时间：15 April 2010
• 年：2010
• 卷：291
• 期：1-2
• 页码：12-16
• 全文大小：280 K

文摘

In Parkinson's disease, cell death is selectively induced in mesencephalic nigral dopaminergic neurons. At present, no disease modifying therapy or radical treatment has been found for this disease. Some dopamine agonists may have a neuroprotective action in cultured cells and animal models. In the present study, we examined stimulating effects of a non-ergoline D₂ dopamine agonist, ropinirole, on synthesis/secretion of neurotrophic factors, including NGF, BDNF, and GDNF, in cultured mouse astrocytes. These effects were compared with those of ergoline dopamine agonists, SKF-38393, a D₁ agonist, bromocriptine, D₂ agonist, and apomorphine, D₁/D₂ agonist. Ropinirole elevated GDNF levels to 4-fold, and NGF levels to 6.3-fold, compared with the control group. Of the dopamine agonists examined, ropinirole produced and secreted more GDNF than a 1.8-fold greater amount of apomorphine, a lesser amount of bromocriptine, or a 2.8-fold greater amount of SKF-38393, which served as the control group.