Endomyocardial proteomic signature corresponding to the response of patients with dilated cardiomyopathy to immunoadsorption therapy
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- 作者：Gourav Bhardwaja ; d ; 1 ; Marcus Dö ; rrb ; d ; 1 ; Praveen Kumar Sappaa ; Sabine Amelinga ; d ; Vishnu Dhoplea ; Leif Steila ; Karin Klingelc ; Klaus Empenb ; Daniel Beugb ; Uwe Vö ; lkera ; d ; Stephan B. Felixb ; d ; felix@uni-greifswald.de" class="auth_mail" title="E-mail the corresponding author ; Elke Hammera ; d ; hammer@uni-greifswald.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dilated cardiomyopathy ; Therapy response ; Endomyocardial biopsies ; Label-free tandem mass spectrometry ; Multiple reaction monitoring
- 刊名：Journal of Proteomics
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：150
- 期：Complete
- 页码：121-129
- 全文大小：870 K
文摘
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Exploration of reasons for variation of response of DCM patients to therapy by IA/IgG vary.
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Myocardial proteome profiling of responders and non-responders was performed.
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Patient subgroups differ in energy and lipid metabolism, immune system and cardioprotection.
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Most prominent differences were found for proteins S100-A8, perilipin-4, and kininogen-1.
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Biomarker potential of these three proteins was evaluated.