A rational approach towards the design of chitosan-based nanoparticles obtained by ionotropic gelation
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- 作者：H. Kleine-Brueggeney ; G.K. Zorzi1 ; T. Fecker ; N.E. El Gueddari ; B.M. Moerschbacher ; F.M. Goycoolea ; goycoole@uni-muenster.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan ; Nanoparticles ; Degree of acetylation ; Coil overlap parameter ; Molecular weight ; Ionotropic gelation
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：135
- 期：Complete
- 页码：99-108
- 全文大小：2189 K
文摘
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Nanoparticles of chitosan–sodium tripolyphosphate (CS-TPP) are formed in the dilute and semidilute regime.
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The degree of coil space-occupancy (product of concentration and intrinsic viscosity) is a fundamental parameter to consider in the preparation of CS-TPP nanoparticles.
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In general, the size and zeta potential of the nanoparticles are determined by the the degree of acetylation (DA) of CS.
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Two type of behaviors are recognized at low (DA < 30%) or high (DA > 30%).
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The molar ratio of glucosamine/TPP accounts for the DA of CS and also determine the physical properties of the nanoparticles.