Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D

详细信息    查看全文

• 作者：Ale&scaron ; Doli&scaron ; ka^a ; ^{ales.doliska@uni-mb.si} ; Volker Ribitsch^b ; ¹ ; Karin Stana Kleinschek^b ; ¹ ; Simona Strnad^a ; ¹
• 关键词：QCM-D ; Fibrinogen ; Adsorption ; Modelling ; Haemocompatibility
• 刊名：Carbohydrate Polymers
• 出版年：2013
• 出版时间：1 March, 2013
• 年：2013
• 卷：93
• 期：1
• 页码：246-255
• 全文大小：1462 K

文摘

In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.