Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids

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• 作者：Qiyu Chen^a ; ¹ ; Caixia Li^a ; ^b ; ¹ ; Zhiyuan Gong^b ; Eric Chun Yong Chan^c ; Shane A. Snyder^d ; Siew Hong Lam^a ; ^b ; ^{dbslsh@nus.edu.sg}
• 关键词：Zebrafish ; Microarray ; Transcriptome ; Glucocorticoids ; Environmental-relevant
• 刊名：Chemosphere
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：172
• 期：Complete
• 页码：429-439
• 全文大小：1669 K
• 卷排序：172

文摘

Identified 159 unique homologs deregulated commonly by glucocorticoids. Homologs associated with over 20 molecular functions and 3 signalling pathways. Nervous, hepatic, endothelial-vascular and myeloid cell systems affected in larvae. cry2b, fbxo32, klhl38b responded robustly to environmental concentrations. Findings useful to infer biological impacts of glucocorticoid exposure in fish.