The reactivity of lactyl-oxythiamin implies the role of the amino-pyrimidine in thiamin catalyzed decarboxylation
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- 作者：Yasaman Heidari1 ; Graeme W. Howe ; Ronald Kluger ; r.kluger@utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oxythiamin ; Thiamin ; Lactyl-oxythiamin synthesis ; Lactyl-oxythiamin decarboxylation ; Aminopyrimidine function ; 2-ketoacid decarboxylases ; Acyl carbanion equivalent ; Nucleophilic carbene ; Hydrogen bond
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：153-158
- 全文大小：602 K
文摘
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LOTh, the conjugate of oxythiamin and pyruvate, was synthesized.
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LOTh decarboxylates at only 1/4 the rate of the thiamin conjugate.
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The rate variation is associated with differences in H-bonding.