Individuals with a low lifetime risk for cardiovascular disease (CVD) have a low burden of traditional risk factors.
Despite this low lifetime risk, there are still CVD events over 10 year follow-up.
High amounts of coronary artery calcification (CAC) was the only predictor of CVD among a low lifetime risk population.
Those without CAC had the lowest absolute event rates.
The utility of CAC testing across the CVD risk spectrum warrants more attention.