Elucidation of the Absolute Configuration of Knipholone and Knipholone Anthrone by Quantum Chemical CD Calculations
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- 作者：Bringmann ; Gerhard ; Kraus ; Jü ; rgen ; Menche ; Dirk ; Messer ; Kim
- 关键词：Knipholone (anthrone) ; axial chirality ; circular dichroism ; quantum chemical calculations
- 刊名：Tetrahedron
- 出版年：1999
- 出版时间：June 11, 1999
- 年：1999
- 卷：55
- 期：24
- 页码：7563-7572
- 全文大小：414 K
文摘
The absolute configuration of knipholone, an axially chiral phenylanthraquinone from Kniphofia, Bulbine, and Bulbinella species, has been established as M by quantum chemical CD calculations. For further evidence, the absolute stereostructure of the related compound knipholone anthrone, which has a significantly different chromophor, was likewise elucidated. The fact that both natural biaryls compounds were independently attributed the same absolute configuration, underlines the reliability of the results and the value of the applied method.