Cortical interleukin-1β elevation after traumatic brain injury in the rat: no effect of two selective antagonists on motor recovery

详细信息    查看全文

• 作者：Knoblach ; Susan M. ; Faden ; Alan I.
• 关键词：Interleukin-1 ; Interleukin-1 receptor antagonist ; Soluble receptors ; Expression ; Neurological dysfunction ; Brain injury
• 刊名：Neuroscience Letters
• 出版年：2000
• 出版时间：July 28, 2000
• 年：2000
• 卷：289
• 期：1
• 页码：5-8
• 全文大小：209 K

文摘

Interleukin-1 is an inflammatory cytokine implicated in secondary responses to traumatic brain injury. We utilized a specific IL-β enzyme-linked immunoadsorbant assay to examine the expression of IL-β after lateral fluid percussion brain injury in the rat. IL-β was significantly elevated in the ipsilateral injured cortex at 4 h after injury. Increased levels of IL-β were also observed at 12, 24 and 72 h after injury, although such changes did not reach statistical significance. To determine whether injury-induced IL-β expression may contribute to subsequent neurological impairment, we treated rats with either of two structurally different, selective IL-1 antagonists and monitored neurological recovery 1, 7 and 14 days later. Intracerebroventricular treatment with either the endogenous interleukin-1 receptor antagonist (10 μg) at 15 min, 2, 4, 6, and 8 h after injury or soluble IL-1 receptors (10 μg) at 15 min, 4 and 8 h after injury did not significantly alter outcome in a series of motor tasks. These data suggest that cortical elevations of IL-β follow traumatic brain injury, but they may not contribute to subsequent neurological impairment.