- 作者：Junichiro Fukuda ; j-fukuda@towako-kato.com" class="auth_mail" title="E-mail the corresponding author ; Takashi Abe ; Takashi Okuno ; Tamotsu Kobayashi ; Keiichi Kato
- 关键词：Follicle maturation trigger ; Human chorionic gonadotropin ; Iatrogenic infertility ; Natural-cycle in vitro fertilization ; Persistent follicle ; Subsequent menstrual cycle
- 刊名：International Journal of Gynecology and Obstetrics
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：132
- 期：3
- 页码：309-313
- 全文大小：211 K
Methods
Patients that were infertile undergoing natural-cycle in vitro fertilization at Kato Ladies Clinic, Japan, between March and June 2012 were enrolled in a prospective cohort study. Patients who had received fertility treatments other than hCG injections were excluded from the study. The remaining patients were divided into two cohorts; patients who had received injection-administered hCG (study group) and patients who had not received any fertility treatment (control group) during their preceding menstrual cycle. The rates of oocyte retrieval, fertilization, clinical pregnancy, and live deliveries were analyzed using a Fisher exact test.
Results
The rate of successful oocyte-retrieval (P < 0.001) and the delivery-rate (P = 0.002) were significantly lower in the study group in comparison with the control group. Additionally, the incidence of empty follicles (P < 0.001) and degenerated oocytes (P = 0.002) was significantly higher in the exposure group.
Conclusion
Triggering follicle maturation with hCG during in vitro fertilization could impact patient fertility during their next cycle. Treatment with hCG injection has the potential to influence not only the cycle during which it is administered, but also the subsequent menstrual cycle.