Development and validation of an LC-MS/MS method for the determination of tofogliflozin in plasma and its application to a pharmacokinetic study in rats
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- 作者：Shinji Kobuchi ; Megumi Matsuno ; Etsuko Fukuda ; Yukako Ito ; Toshiyuki Sakaeda ; sakaedat@mb.kyoto-phu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：LC&ndash ; MS/MS ; Tofogliflozin ; Rat plasma ; Antidiabetic agent
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：1027
- 期：Complete
- 页码：227-233
- 全文大小：843 K
文摘
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A rapid and sensitive LC–MS/MS method was developed for tofogliflozin quantification in rat plasma.
The method has a low quantification limit of 0.5 ng/mL and short run time of 4 min.
Plasma concentration was quantified at least 24 h after oral administration of 0.4 mg/kg tofogliflozin to rats.