Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury
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- 作者：Toshiki Okubo1 ; 2 ; Akio Iwanami1 ; Jun Kohyama2 ; Go Itakura2 ; Soya Kawabata1 ; Yuichiro Nishiyama1 ; Keiko Sugai1 ; Masahiro Ozaki1 ; 2 ; Tsuyoshi Iida1 ; 2 ; Kohei Matsubayashi1 ; 2 ; Morio Matsumoto1 ; Masaya Nakamura1 ; masa@a8.keio.jp" class="auth_mail" title="E-mail the corresponding author ; Hideyuki Okano2 ; hidokano@a2.keio.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：7
- 期：4
- 页码：649-663
- 全文大小：4019 K
文摘
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GSI-treated hiPSC-NS/PCs induced neuronal differentiation and maturation
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GSI-treated hiPSC-NS/PCs integrated into the reconstructed host neuronal network
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Grafted GSI-treated hiPSC-NS/PCs prevented tumor-like overgrowth following SCI
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Grafted GSI-treated hiPSC-NS/PCs maintained functional recovery following SCI