Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia
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- 作者：Hiroyuki Maruyamaa ; Takamasa Katagirib ; Koichi Kashiwasec ; Takashi Shiinad ; Aiko Sato-Otsuboe ; Yoshitaka Zaimokua ; Kana Maruyamaa ; Kohei Hosokawaa ; Ken Ishiyamaa ; Hirohito Yamazakia ; Hidetoshi Inokod ; Seishi Ogawae ; Shinji Nakaoa ; snakao8205@staff.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Experimental Hematology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：10
- 页码：931-939.e3
- 全文大小：1843 K
文摘
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HLA-A allele-lacking leukocytes (HLA-LLs) were detected in 25.4% of newly diagnosed patients with aplastic anemia.
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The presence of HLA-LLs at diagnosis was strongly related to good clinical outcomes.
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T-cell attacks against hematopoietic progenitor cells can trigger bone marrow failure.