Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3
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- 作者：Yuki Yoshizaki ; Yutaro Mori ; Yoshihito Tsuzaki ; Takayasu Mori ; Naohiro Nomura ; Mai Wakabayashi ; Daiei Takahashi ; Moko Zeniya ; Eriko Kikuchi ; Yuya Araki ; Fumiaki Ando ; Kiyoshi Isobe ; Hidenori Nishida ; Akihito Ohta ; Koichiro Susa ; Yuichi Inoue ; Motoko Chiga ; Tatemitsu Rai ; Sei Sasaki ; Shinichi Uchida ; Eisei Sohara ; esohara.kid@tmd.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：PKA ; Akt ; KLHL3 ; WNK4 ; Insulin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：13 November 2015
- 年：2015
- 卷：467
- 期：2
- 页码：229-234
- 全文大小：503 K
文摘
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Phosphorylation of KLHL3 at S433 inhibits the binding between KLHL3 and WNK4.
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PKA phosphorylates KLHL3 at S433, inhibiting KLHL3 effect for WNK4 degradation.
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Akt and insulin phosphorylate KLHL3 at S433.