Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke
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- 作者：Kuniyuki Nakamuraa ; b ; 1 ; kunakamu@intmed2.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Koichi Arimurab ; c ; 1 ; Ataru Nishimurab ; c ; Masaki Tachibanab ; Yoji Yoshikawab ; Noriko Makiharab ; Yoshinobu Wakisakab ; Junya Kurodab ; Masahiro Kamouchid ; Hiroaki Ooboshia ; Takanari Kitazonob ; Tetsuro Agob ; agou@intmed2.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNS ; central nervous system ; BBB ; blood&ndash ; brain barrier ; PDGF ; platelet-derived growth factor ; PDGFRβ ; platelet-derived growth factor receptor β ; bFGF ; basic fibroblast growth factor ; FGFR ; fibroblast growth factor receptor ; MCA ; middle cerebral artery ; pMCAO ; permanent middle cerebral artery occlusion ; tMCAO ; transient middle cerebral artery occlusion ; GFAP ; glial fibrillary acidic protein ; CREB ; cAMP responsive element binding protein ; VEGF ; vascular endothelial growth factor ; NGF ; nerve g
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：1630
- 期：Complete
- 页码：98-108
- 全文大小：2955 K
文摘
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bFGF upregulates the expression of PDGFRβ in CNS pericytes.
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bFGF is upregulated by acidification in pericytes.
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bFGF and FGFR1 are induced in peri-infarct areas after brain ischemia.
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bFGF and FGFR1 are co-localized with PDGFRβ-positive cells after brain ischemia.
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bFGF enhances the proliferation and migration of pericytes through PDGFRβ.