Circadian rhythm of apoprotein H (β2-glycoprotein-1) in human plasma

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• 作者：Masashi Higashimoto ; Yoshimi Homma ; Miyuki Umetsu ; Yuri Konno ; Koichiro Ono ; Nobuhiro Yoshimoto ; Tomoyuki Momma ; Masaru Saito ; Seiichi Takenoshita ; Yuji Takebayashi
• 关键词：Circadian rhythm ; Apoprotein H ; Human plasma
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2007
• 出版时间：24 August 2007
• 年：2007
• 卷：360
• 期：2
• 页码：418-422
• 全文大小：437 K

文摘

Many physiological, biochemical, and behavioral processes are under circadian regulation, which is generated by an internal time-keeping mechanism referred to as biological clock. The regulators of circadian rhythm in human plasma have not been completely elucidated. Here we demonstrated that the isolated protein from human plasma, which down-regulated expression level of cry1 in Jurkat cells, was apoprotein H (ApoH). Further, mRNA expression level of ApoH indicated circadian rhythm in Jurkat cells. The concentration of ApoH was subject to circadian rhythm in human plasma. These experimental results suggested that ApoH may be one of the members of the regulator of circadian rhythm and that ApoH expression level was also dependent on circadian rhythm in Jurkat cells and in human plasma.