Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling
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- 作者：Samia Habbas1 ; 6 ; Mirko Santello1 ; 6 ; 7 ; Denise Becker1 ; Hiltrud Stubbe1 ; Giovanna Zappia1 ; Nicolas Liaudet1 ; Federica R. Klaus2 ; George Kollias3 ; Adriano Fontana4 ; Christopher R. Pryce2 ; Tobias Suter5 ; Andrea Volterra1 ; andrea.volterra@unil.ch" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：163
- 期：7
- 页码：1730-1741
- 全文大小：2982 K
文摘
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Pathological levels of TNFα cause persistent synaptic alteration in the hippocampus
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Astrocyte TNFR1 mediates the synaptic effect of TNFα
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Hippocampal inflammation and synaptic alteration occur in a multiple sclerosis model
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Astrocyte TNFR1 is necessary for synaptic alterations and ensuing cognitive pathology