Relationship between serum IgG4 concentrations and atherosclerotic coronary plaques assessed by computed tomographic angiography

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• 作者：Aiko Sakamoto ; MD ; PhD^a ; ^{asakamoto-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Nobukazu Ishizaka ; MD ; PhD ; FJCC^b ; Yasushi Imai ; MD ; PhD^a ; ^c ; Masae Uehara ; MD ; PhD^a ; Jiro Ando ; MD^a ; Ryozo Nagai ; MD ; PhD ; FJCC^a ; ^d ; Issei Komuro ; MD ; PhD ; FJCC^a
• 关键词：IgG4 ; Immuno-inflammation ; Coronary plaque vulnerability ; Biomarkers ; Coronary computed tomographic angiography
• 刊名：Journal of Cardiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：67
• 期：3
• 页码：254-261
• 全文大小：570 K

文摘

Immunoglobulin G4 (IgG4)-related immuno-inflammation has been suggested to affect the development of coronary artery atherosclerosis. The aim of this study was to analyze the association of serum IgG4 concentrations with calcified and non-calcified coronary plaques.

id="absSec_2">Methods

id="spar0010">Serum IgG4 concentrations were measured in 263 patients who underwent 320-slice coronary computed tomographic (CT) angiography. Vulnerable coronary plaques were evaluated for CT plaque characteristics, including low-density plaque (LDP), positive remodeling, and spotty calcification.

id="absSec_3">Results

id="spar0015">Serum concentrations of IgG4 were significantly higher in patients with non-calcified plaque (NCP) than in those without (32.2 mg/dL vs. 23.7 mg/dL, p = 0.029). By contrast, the median serum IgG4 concentrations in patients with and without calcified plaque were 31.2 mg/dL and 26.2 mg/dL, respectively (p = 0.107). Serum IgG4 concentrations were significantly elevated in patients with LDP (33.5 mg/dL vs. 26.9 mg/dL, p = 0.002) and in those with positive remodeling (31.4 mg/dL vs. 28.4 mg/dL, p = 0.039) than in those without. Patients with spotty calcification also had significantly higher serum IgG4 concentrations than those without (32.1 mg/dL vs. 24.9 mg/dL, p = 0.049). In age- and gender-adjusted logistic regression analysis, the highest IgG4 quartile (≥56.7 mg/dL) was significantly associated with LDP with an odds ratio of 2.49 (95% CI, 1.15–5.36, p = 0.020).

id="absSec_4">Conclusions

id="spar0020">Serum IgG4 concentrations were significantly associated with NCP, especially with LDP, suggesting that IgG4-related immuno-inflammation may play a role in coronary plaque vulnerability.